Crystallization Course
This course equips you with practical techniques to excel in crystallizing organic APIs. You will learn solvent selection, seeding, cooling profiles, PAT implementation, and scale-up strategies. Develop robust processes ensuring control over crystal size, polymorphs, filtration, and drying for superior product consistency and quality across batches.

from 4 to 360h flexible workload
valid certificate in your country
What will I learn?
Gain essential skills to create reliable crystallization processes for organic APIs. Master concepts like polymorphism, solubility, supersaturation, cooling strategies, seeding techniques, and solvent choices. Explore mixing effects, hydrodynamics, PAT tools, and data-driven methods to control crystal size, filtration, drying, and batch uniformity. Receive practical advice on experiments, risk evaluation, and effective scale-up procedures.
Elevify advantages
Develop skills
- Design crystallization processes by adjusting solubility, supersaturation, and crystal habit efficiently.
- Engineer precise crystal sizes using optimized cooling, seeding, and mixing for uniform CSD.
- Control polymorph formation through solvent, antisolvent, and solid form risk management.
- Implement PAT tools like FBRM, turbidity, and spectroscopy for real-time process monitoring.
- Scale up reliably by integrating lab DoE, hydrodynamics, and risk analysis with plant operations.
Suggested summary
Before starting, you can change the chapters and the workload. Choose which chapter to start with. Add or remove chapters. Increase or decrease the course workload.What our students say
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