Lesson 1Milling and sieving equipment: oscillating mills, conical mill, hammer mill, sieves — particle size targets and feed controlReviews oscillating, conical, and hammer mills plus sieving systems. Stresses particle size goals, screen picking, feed control, heat making, and metal checks to get steady granule features and good later performance.
Oscillating mill operation and usesConical mill design and screen choicesHammer mill impact and heat controlSieving systems and mesh selectionFeed rate, segregation and metal checksLesson 2Granulation equipment: high-shear granulator, oscillating granulator, twin-screw granulator — process overview and when to useDetails high-shear, oscillating, and twin-screw granulators, comparing ways they work, process parts, and growing scale. Discusses adding binder, finding end point, and rules for picking equipment based on recipe and wanted granule features.
High-shear granulator design and controlOscillating granulator uses and limitsTwin-screw wet granulation principlesBinder addition and endpoint detectionChoosing granulation route for a productLesson 3Primary packaging equipment: blister machines, bottle filling, capping — selection based on product and marketLooks at blister, bottle filling, and capping lines, focusing on picking equipment by product needs, stability, and market. Deals with line setup, changing over, in-process checks, and testing package strength.
Blister machine types and key parametersBottle filling line design and controlCapping systems and torque verificationPackaging selection by product stabilityIn-process checks and package integrityLesson 4Drying equipment: tray dryer vs fluid bed dryer — drying kinetics, typical parameters and monitoringCompares tray and fluid bed dryers, covering drying ways, heat and mass move, and usual process parts. Discusses finding end point, sampling, and checks to avoid breaking down, hard cases, or uneven moisture.
Tray dryer airflow and loading patternsFluid bed dryer design and fluidizationDrying kinetics and critical moistureTypical temperature and airflow rangesMoisture endpoint tests and samplingLesson 5Lubrication and final blending equipment: tumble blender, low-shear blending best practices to avoid over-lubricationExplores lubrication and final blending equipment, stressing tumble and low-shear blenders. Covers picking lubricant, order of adding, blend time, sampling, and checks to stop too much lubrication and ensure even content.
Tumble blender design and operating parametersLow-shear blending and scale-up concernsOrder of addition and lubricant distributionDetecting and preventing over-lubricationIn-process controls for final blend qualityLesson 6Weighing and dispensing: floor/bench scales, electronic balance calibration, batch reconciliation and checksFocuses on weighing and dispensing work, including floor and bench scales, balance tuning, and surroundings effects. Explains identifying materials, clearing lines, batch matching, and paperwork to follow good manufacturing rules.
Scale selection and installation checksBalance calibration and verificationEnvironmental effects on weighingMaterial ID, labeling and line clearanceBatch reconciliation and discrepancy handlingLesson 7Compression and tooling: rotary tablet press basics, turret speed, fill depth, tooling selection and punch maintenanceCovers rotary tablet press build, turret speed, fill depth, and dwell time. Explains tool types, punch tip design, and upkeep to stop faults, cut wear, and keep steady tablet quality and output.
Rotary tablet press components and functionsTurret speed, dwell time and outputDie fill depth and weight controlTooling selection and punch tip designPunch inspection, cleaning and maintenanceLesson 8Coating equipment fundamentals: pan coating basics vs perforated pan and rationale for optional film coatingIntroduces coating pans and perforated pans, atomization, and drying areas. Explains film coating recipe, process parts, and when coating is optional for stability, hiding taste, marking, or changed release.
Conventional vs perforated coating pansSpray guns, atomization and droplet sizeBed temperature and exhaust controlFilm coating formulation componentsReasons for applying or omitting coatingLesson 9Blending equipment: V-blender, bin blender, high-shear mixer — operating principles and suitabilityDescribes V-blenders, bin blenders, and high-shear mixers, comparing mixing ways, scale-up, and blend evenness testing. Guides picking equipment based on powder flow, density, and separation risk for strong blending.
V-blender geometry and mixing patternsBin blender use in contained handlingHigh-shear mixer for cohesive powdersBlend uniformity sampling strategiesSelecting blenders by powder propertiesLesson 10Raw material receipt, sampling and storage equipment: sacks, drums, sampling thief, controlled storage conditions, documentationDeals with receiving raw materials, sampling, and storage equipment, including containers, sampling tools, and controlled places. Covers labeling, status control, paperwork, and separation to keep track and stop mix-ups.
Receipt checks and container inspectionSampling plans and thief use controlsStorage conditions and monitoringLabeling, status labels and quarantineDocumentation, traceability and audits
