Lesson 1Pressing Tablets: How the Tablet Press Works, Tools, Feed System, Weight Checks, and Main ProblemsThis lesson talks about the parts of a tablet press machine, how to set it up, and how to run it. It covers taking care of tools, controlling weight and hardness, and fixing common issues like cracking, splitting, or sticking, with ways to solve them simply.
Types of presses, main parts, and safety guardsPicking, checking, and cleaning toolsDesign of feed system and powder flow problemsControlling weight, hardness, and thicknessCracking, splitting, sticking, and picking issuesLesson 2Ways to Granulate: Wet Granulation Steps, Machine Use, and Key SettingsThis lesson details the steps in wet granulation, choosing binders, and types of machines. It explains important settings, scaling up, and cleaning, focusing on controls that make sure granules are good quality, flow well, and work for pressing later.
Preparing binder solution and checksSetting up and running high-shear granulatorFinding the end point and using PAT toolsTransferring granules and wet screening stepsThings to consider for scaling up and cleaningLesson 3Handling Materials: Active Ingredients, Additives, Sampling, Holding Back, and Release RulesThis lesson reviews how to handle active ingredients and additives from when they arrive until they are released. It covers sampling, holding back, storage, and environment controls, stressing ways to stop mixing up things and decisions based on specs.
Receiving and labeling active ingredients and additivesSampling plans, tools, and risk of contaminationHolding back, approved, and rejected statusStorage conditions and separation rulesReviewing COA, testing, and release rulesLesson 4Packing: Blister Line Work, Checks for Strength, Labeling, and Tracking Each ItemThis lesson describes main and outer packing for solid oral medicines, focusing on blister lines. It covers forming, feeding, sealing, marking, checking, labeling, and tracking, with controls to keep the product's identity and strength safe.
Steps in forming, feeding, and sealing blistersCartoning, putting in leaflets, and bundlingOnline vision systems and seal strength checksMarking, tracking, and groupingRecords for packing line and yieldsLesson 5Direct Pressing: If Formulation Fits, Choosing Additives, and Process ChecksThis lesson focuses on if direct pressing works, including properties of active ingredients, choosing additives, and flow. It explains lubrication, risks of separation, and controls needed for strong tablets without granulating first.
Properties of active ingredients key for direct pressingPicking fillers, binders, and break-apart agentsUsing pre-granulated and co-processed additivesLubricant amount, mixing order, and effectsProcess checks and common failure modesLesson 6Coating and Other Steps (Short): When to Use and Basic Process ThoughtsThis lesson introduces film coating and other steps like printing and capsule marking. It outlines when coating is needed, key process changes, basic machines, and common faults with ways to fix them.
Purposes of functional and non-functional coatingBasics of coating pan and spray systemControl of inlet air, exhaust, and spray rateCommon coating faults and causesPrinting, pressing marks, and capsule markingLesson 7Drying and Grinding: Moisture Control, Drying Checks, Particle Size Reduction and Its EffectsThis lesson explains drying basics, moisture limits, and dryer types. It covers how to load, find end point, and check drying, then connects grinding, particle size spread, and heat to even mixing and pressing.
Moisture goals and loss on drying testsBasics of fluid bed and tray dryer operationDrying end point, sampling, and checksTypes of grinding machines and key settingsEffects of particle size on flow, pressing, and faultsLesson 8Handover Between Steps: Line Clearing, Material Moving, and Sampling Points During ProcessThis lesson explains controlled handover between steps, including clearing the line, labeling status, and moving materials. It details sampling points during process, duties, and records to avoid mix-ups and missing data.
Scope of line clearing and recordsLabels for material status and moving rulesDefined roles and duties for handoverPlans and places for sampling during processHandling samples, storage, and chain of custodyLesson 9Mixing and Blending Basics: Even Blend, Separation Risks, Mixing ChecksThis lesson explains how mixing works, types of blenders, and testing for even blend. It covers separation risks, order of adding, scaling up, and ways to check mixing to show it is strong and repeatable.
Types of blenders and loading waysMixing ways and time to mixSampling plans for even blend testsCauses of separation and ways to stop itChecking mixing and ongoing checksLesson 10Weighing and Dispensing: Steps, Accuracy, Tare, and TrackingThis lesson covers design of weighing room, qualifying balances, and right use of tare. It explains sampling, identifying, matching, labeling, and tracking controls for accurate dispensing and full material history.
Zoning of weighing room and environment controlsCalibrating, checking, and maintaining balancesTare steps and reducing handling mistakesMaterial ID, labels, and status controlWeighing records, matching, and historyLesson 11Overview of Making Tablets and Capsules from Raw Materials to Final PackingThis lesson maps the whole making flow from receiving raw materials to finished packs. It highlights records, sampling, checks during process, and decision points, connecting each stage to good practices, data truth, and batch release needs.
Receiving raw materials, sampling, and testingIssuing batch records and preparing lineMain processing through pressing or fillingCoating, printing, and visual checksFinal packing, quality review, and release
