Lesson 1Oxygen therapy and adjunctive measures: indications for supplemental oxygen and non-invasive ventilationReviews when to give extra oxygen and non-invasive breathing help in ACS, stressing no routine oxygen if levels normal, start points, device picks, and linking with blood flow and pain control.
Evidence against routine oxygen in normoxiaSpO2 thresholds to start supplemental oxygenChoosing nasal cannula vs mask vs HFNCIndications for CPAP or BiPAP in ACSMonitoring respiratory status and escalationLesson 2Reperfusion decision-making: criteria for primary PCI vs fibrinolysis vs conservative managementGuides reopening choices in STEMI and some NSTEMI, listing rules for main PCI, when clot-busters fit, time limits, no-go factors, and when watchful care suits based on blood lack and bleed risks.
STEMI criteria and symptom onset timingDoor-to-balloon and door-to-needle goalsAbsolute and relative lysis contraindicationsWhen to choose primary PCI over lysisConservative strategy in high-risk NSTEMILesson 3Fibrinolytic agents: indications, dosing (tenecteplase, alteplase), contraindications, and management of bleeding complicationsCovers clot-buster therapy for STEMI if PCI delayed, weight doses for tenecteplase/alteplase, extra blood thinners, strict no-gos, and spotting/handling bleeds.
STEMI patients eligible for fibrinolysisTenecteplase dosing by weight and ageAlteplase STEMI dosing protocolsAdjunct aspirin and anticoagulation useManaging intracranial and systemic bleedingLesson 4Special scenarios: cardiogenic shock, cardiac arrest with STEMI, right ventricular infarction — tailored reperfusion and pharmacologic adjustmentsHandles tough ACS cases like heart shock, arrest with STEMI, right heart attack, focusing on custom reopening, blood flow support, and careful tweaks to pressors and active drugs.
Identifying and grading cardiogenic shockMechanical support options in shockPost–cardiac arrest STEMI pathwaysRight ventricular infarction recognitionAdjusting preload, afterload, and inotropesLesson 5Nitrates, morphine, and hemodynamic considerations: indications, contraindications, and administration routesLooks at nitrates and morphine in ACS, signs for pain relief, no-gos like low pressure or right heart attack, giving ways, doses, and effects on vein fill, afterload, heart blood.
Contraindications to nitrate therapySublingual vs IV nitrate administrationMorphine dosing and monitoringImpact on preload and afterloadInteractions with phosphodiesterase-5 inhibitorsLesson 6Renal dysfunction and drug selection: dose adjustments, contrast nephropathy prevention, and anticoagulation changes in CKDFocuses on ACS with kidney issues, dose tweaks for blood thinners/contrast, plans to stop dye kidney harm, fluid handling, balancing blood lack and bleed risks in bad kidney disease.
Estimating kidney function in the EDAdjusting anticoagulants in CKD and ESRDP2Y12 and statin choices in renal diseaseHydration and contrast minimization tacticsPost-contrast monitoring and nephrology consultsLesson 7Anticoagulation choices in ACS: UFH, bivalirudin, enoxaparin — dosing, monitoring, renal adjustments, and periprocedural considerationsCompares blood thinner options in ACS like UFH, enoxaparin, bivalirudin, stressing doses in STEMI/NSTEMI, checks, kidney tweaks, and handling around PCI or bypass.
UFH bolus and infusion dosing in ACSEnoxaparin dosing and timing with PCIBivalirudin indications and dosingMonitoring ACT, aPTT, and anti-Xa levelsBridging and holding anticoagulants for CABGLesson 8High-intensity statin initiation in ED: rationale, dosing, and hepatic safety checksExplains starting strong statins in ER for ACS, proof for early use, right drugs/doses, liver baseline, enzyme watches, handling statin issues or harm.
Evidence for early statin in ACS outcomesChoosing atorvastatin vs rosuvastatinInitial high-intensity dosing regimensBaseline liver tests and contraindicationsMonitoring and managing hepatic adverse eventsLesson 9Immediate pharmacologic measures for suspected MI: aspirin dosing, P2Y12 inhibitors selection and timing (clopidogrel, prasugrel, ticagrelor)Outlines right-away drug steps for suspected heart attack, stressing quick aspirin, picking and timing P2Y12 blockers, loading doses, mixing with blood thinners and reopening plans, and noting allergies or past drugs.
Aspirin loading dose and formulationsChoosing initial P2Y12 inhibitor in EDTiming of loading relative to PCI or lysisManaging prior DAPT or recent anticoagulantsDocumenting allergies and prior stent historyLesson 10Beta-blockers and ACE inhibitors/ARBs in acute setting: when to give, contraindications, initial dosing and monitoringReviews early beta-blockers and ACEi/ARBs in ACS, timing post-stable, no-gos like shock/slow heart, start doses, ramp-up, checks for low pressure, kidney harm, high potassium.
Hemodynamic criteria before beta-blockersOral vs IV beta-blocker selectionStarting and titrating ACEI or ARBContraindications and caution flagsMonitoring blood pressure, creatinine, potassiumLesson 11Primary PCI pathways: door-to-balloon targets, transfer protocols, pre-PCI medications, and antithrombotic strategyDetails main PCI flows, door-to-balloon goals, start/transfer rules, pre-PCI platelet/blood thinner plans, tweaking thinners for bleed risk and blockage hardness.
ED triage and cath lab activation stepsInterfacility transfer and transport timingPre-PCI aspirin and P2Y12 loadingChoice of UFH, bivalirudin, or enoxaparinPost-PCI antithrombotic continuation plansLesson 12Antiplatelet management in NSTEMI: timing of loading doses before coronary angiography and scenarios favoring conservative vs early invasive approachHandles platelet blockers in NSTEMI, timing aspirin/P2Y12 loads before angio, agent choice, how blood lack/bleed risk, other ills, planned work sway watchful vs early invasive paths.
Risk scores guiding invasive strategyTiming of P2Y12 loading before cathChoosing clopidogrel vs ticagrelor vs prasugrelManaging patients likely to need CABGDe-escalation and duration of DAPT in NSTEMI
