Lesson 1Milling and sieving equipment: oscillating mills, conical mill, hammer mill, sieves — particle size targets and feed controlReviews oscillating, conical, and hammer mills plus sieving systems. Stresses particle size goals, screen choice, feed control, heat buildup, and metal checks for steady granule properties and later performance.
Oscillating mill operation and usesConical mill design and screen choicesHammer mill impact and heat controlSieving systems and mesh selectionFeed rate, segregation and metal checksLesson 2Granulation equipment: high-shear granulator, oscillating granulator, twin-screw granulator — process overview and when to useDetails high-shear, oscillating, and twin-screw granulators, comparing actions, process settings, and scaling. Discusses adding binder, endpoint spotting, and picking equipment based on formulation and granule needs.
High-shear granulator design and controlOscillating granulator uses and limitsTwin-screw wet granulation principlesBinder addition and endpoint detectionChoosing granulation route for a productLesson 3Primary packaging equipment: blister machines, bottle filling, capping — selection based on product and marketLooks at blister, bottle filling, and capping lines, focusing on picking equipment by product sensitivity, stability, and market demands. Covers line setup, changeovers, in-process checks, and pack integrity tests.
Blister machine types and key parametersBottle filling line design and controlCapping systems and torque verificationPackaging selection by product stabilityIn-process checks and package integrityLesson 4Drying equipment: tray dryer vs fluid bed dryer — drying kinetics, typical parameters and monitoringCompares tray and fluid bed dryers, covering drying speed, heat and mass transfer, and usual settings. Discusses endpoint checks, sampling, and controls to avoid damage, hard surfaces, or uneven moisture.
Tray dryer airflow and loading patternsFluid bed dryer design and fluidizationDrying kinetics and critical moistureTypical temperature and airflow rangesMoisture endpoint tests and samplingLesson 5Lubrication and final blending equipment: tumble blender, low-shear blending best practices to avoid over-lubricationExplores lubrication and final blending equipment, stressing tumble and low-shear blenders. Covers lubricant choice, addition order, blend time, sampling, and checks to prevent too much lubrication and ensure uniformity.
Tumble blender design and operating parametersLow-shear blending and scale-up concernsOrder of addition and lubricant distributionDetecting and preventing over-lubricationIn-process controls for final blend qualityLesson 6Weighing and dispensing: floor/bench scales, electronic balance calibration, batch reconciliation and checksFocuses on weighing and dispensing, including floor and bench scales, balance calibration, and surroundings effects. Explains material ID, line clearance, batch checks, and records for GMP compliance.
Scale selection and installation checksBalance calibration and verificationEnvironmental effects on weighingMaterial ID, labeling and line clearanceBatch reconciliation and discrepancy handlingLesson 7Compression and tooling: rotary tablet press basics, turret speed, fill depth, tooling selection and punch maintenanceCovers rotary tablet press build, turret speed, fill depth, and dwell time. Explains tool types, punch tip design, and upkeep to prevent faults, reduce wear, and keep steady tablet quality and output.
Rotary tablet press components and functionsTurret speed, dwell time and outputDie fill depth and weight controlTooling selection and punch tip designPunch inspection, cleaning and maintenanceLesson 8Coating equipment fundamentals: pan coating basics vs perforated pan and rationale for optional film coatingIntroduces coating pans and perforated pans, atomization, and drying areas. Explains film coating mixes, process settings, and when coating helps stability, taste hiding, ID, or controlled release.
Conventional vs perforated coating pansSpray guns, atomization and droplet sizeBed temperature and exhaust controlFilm coating formulation componentsReasons for applying or omitting coatingLesson 9Blending equipment: V-blender, bin blender, high-shear mixer — operating principles and suitabilityDescribes V-blenders, bin blenders, and high-shear mixers, comparing mixing ways, scaling, and uniformity tests. Guides picking equipment based on powder flow, density, and separation risk for reliable blending.
V-blender geometry and mixing patternsBin blender use in contained handlingHigh-shear mixer for cohesive powdersBlend uniformity sampling strategiesSelecting blenders by powder propertiesLesson 10Raw material receipt, sampling and storage equipment: sacks, drums, sampling thief, controlled storage conditions, documentationAddresses raw material receipt, sampling, and storage equipment, including containers, sampling tools, and controlled settings. Covers labeling, status control, records, and separation to keep tracking and avoid mix-ups.
Receipt checks and container inspectionSampling plans and thief use controlsStorage conditions and monitoringLabeling, status labels and quarantineDocumentation, traceability and audits
