Lesson 1Pathophysiology of sepsis and septic shock: host response, organ dysfunction, and progressionCovers the body's reaction to infection, including swelling and defence pathways, small blood vessel issues, and cell problems. Connects these to organ failure, shock worsening, and signs nurses watch closely in real time.
Host immune response to infection in sepsisEndothelial injury and capillary leakMicrocirculatory and mitochondrial dysfunctionFrom sepsis to septic shock: key transitionsOrgan dysfunction patterns and SOFA conceptsClinical correlates of underlying pathophysiologyLesson 2Fluid therapy specifics: crystalloid selection, bolus strategies, and recognition of fluid overloadDiscusses types of fluid salts, push amounts, and speeds for early sepsis revival. Stresses checking fluid response dynamically, spotting overload at bedside, and nurse tactics to balance blood flow without harm.
Balanced versus normal saline selectionInitial bolus strategies and reassessment timingStatic and dynamic fluid responsiveness toolsClinical signs of fluid overload at the bedsideDocumentation of fluid balance and net statusCollaboration on de-resuscitation strategiesLesson 3Patient safety and sepsis-related complications: acute kidney injury, coagulopathy, and need for organ supportLooks at usual sepsis issues like sudden kidney damage, blood clotting problems, breathing failure, and organ help needs. Focuses on quick spotting, prevention plans, and nurse care for kidney, lung, and blood support.
Recognition and staging of acute kidney injuryCoagulopathy, DIC, and bleeding riskRespiratory failure and ventilatory supportHemodynamic support beyond vasopressorsNursing care for renal replacement therapyPrevention and early detection of complicationsLesson 4Documentation and communication: recording bundle elements, escalation triggers, and handover of sepsis careExplains precise recording of sepsis care packs, vital sign changes, and actions, plus clear alerts for worsening. Stresses handover formats, feedback loops, and lists to keep care flowing smoothly.
Recording sepsis bundle elements and timingDocumenting hemodynamics and lactate trendsEscalation triggers and rapid response criteriaStructured handover tools for sepsis patientsInterdisciplinary communication best practicesLegal and quality implications of documentationLesson 5Antimicrobial stewardship and timing: empirical therapy selection, de-escalation, and culture stewardshipEmphasises quick start of broad antibiotics, doses, and giving in sepsis. Covers taking samples, reviewing with new info, scaling down, and nurse duties in wise antibiotic use and side effect watch.
Timing of first-dose antibiotics in sepsisEmpirical regimen selection and local antibiogramsObtaining cultures without delaying therapyDe-escalation and duration of therapyMonitoring for antimicrobial adverse effectsNursing contributions to stewardship roundsLesson 6Vasopressors and inotropes: indications, dosing targets, titration, adverse effects, and common nurse-driven protocols for norepinephrineReviews noradrenaline as top blood pressure booster in septic shock, covering when to use, start doses, adjustments, targets, side effects, and nurse-led plans with safety steps and line checks.
Indications for norepinephrine in septic shockStarting doses, concentration, and titration stepsMAP targets and hemodynamic monitoringRecognition and management of adverse effectsCentral line use, patency, and extravasation careNurse-driven vasopressor titration protocolsLesson 7Current international sepsis guidelines and bundles (Surviving Sepsis Campaign): 1‑hour and 3‑hour elementsOutlines latest Surviving Sepsis Campaign rules and packs, focusing on 1-hour and 3-hour steps. Highlights urgent nurse tasks, adapting to local ways, and review processes to boost compliance and results.
Core principles of Surviving Sepsis CampaignOne-hour bundle elements and nurse actionsThree-hour bundle elements and sequencingIntegrating bundles into unit workflowsMeasuring compliance and feedback loopsAdapting guidelines to local resourcesLesson 8Hemodynamic goals in sepsis: MAP targets, lactate-guided resuscitation, and fluid responsiveness assessmentSets blood flow targets in sepsis like MAP aims, lactate drop, and flow signs. Reviews bedside fluid checks using movement tests, scans, and nurse sense for revival choices.
MAP targets and individualized blood pressure goalsLactate trends and perfusion-guided resuscitationCapillary refill and peripheral perfusion markersDynamic indices for fluid responsivenessRole of bedside ultrasound in volume assessmentBalancing fluids, vasopressors, and inotropesLesson 9Monitoring response to sepsis treatment: serial lactates, urine output, end-organ perfusion markers, and bedside clinical toolsShows tracking sepsis response with repeat lactates, urine amounts, alertness, and organ signs. Includes bedside aids, check frequency, and records to steer continued revival or scaling back.
Serial lactate measurement and interpretationUrine output targets and renal perfusionNeurologic status and delirium screeningSkin, temperature, and perfusion assessmentFrequency and structure of reassessment roundsTrend-based documentation and care adjustmentsLesson 10Infection source control: principles, timelines, and nursing coordination for procedures and diagnosticsOutlines stopping infection sources, timing, teamwork for scans and fixes, and nurse talks. Covers prep, moving patients, consent aid, and after-care watch.
Identifying likely infection sources earlyTiming and urgency of source control actionsCoordinating imaging and bedside proceduresPreprocedure preparation and safety checksPostprocedure monitoring and complication signsNursing role in multidisciplinary planning
