Lesson 1Millin an sievin equipment: oscillatin mills, conical mill, hammer mill, sieves — particle size targets an feed controlReview oscillatin, conical, an hammer mills plus sievin systems. Emphasize particle size targets, screen selection, feed control, heat generation, an metal control fi achieve consistent granule properties an downstream performance.
Oscillatin mill operation an usesConical mill design an screen choicesHammer mill impact an heat controlSievin systems an mesh selectionFeed rate, segregation an metal checksLesson 2Granulation equipment: high-shear granulator, oscillatin granulator, twin-screw granulator — process overview an when fi useDetail high-shear, oscillatin, an twin-screw granulators, comparin mechanisms, process parameters, an scale-up. Discuss binder addition, endpoint detection, an criteria fi choosin equipment base pon formulation an desired granule properties.
High-shear granulator design an controlOscillatin granulator uses an limitsTwin-screw wet granulation principlesBinder addition an endpoint detectionChoosin granulation route fi a productLesson 3Primary packagin equipment: blister machines, bottle fillin, cappin — selection base pon product an marketExamine blister, bottle fillin, an cappin lines, focusin pon equipment selection by product sensitivity, stability, an market needs. Address line layout, changeover, in-process controls, an packagin integrity testin requirements.
Blister machine types an key parametersBottle fillin line design an controlCappin systems an torque verificationPackagin selection by product stabilityIn-process checks an package integrityLesson 4Dryin equipment: tray dryer vs fluid bed dryer — dryin kinetics, typical parameters an monitorinCompare tray an fluid bed dryers, coverin dryin kinetics, heat an mass transfer, an typical process parameters. Discuss endpoint determination, samplin, an controls fi avoid degradation, case hardenin, or non-uniform moisture.
Tray dryer airflow an loadin patternsFluid bed dryer design an fluidizationDryin kinetics an critical moistureTypical temperature an airflow rangesMoisture endpoint tests an samplinLesson 5Lubrication an final blendin equipment: tumble blender, low-shear blendin best practices fi avoid over-lubricationExplore lubrication an final blendin equipment, emphasizin tumble an low-shear blenders. Cover lubricant selection, order a addition, blend time, samplin, an controls fi prevent over-lubrication an ensure content uniformity.
Tumble blender design an operatin parametersLow-shear blendin an scale-up concernsOrder a addition an lubricant distributionDetectin an preventin over-lubricationIn-process controls fi final blend qualityLesson 6Weighin an dispensin: floor/bench scales, electronic balance calibration, batch reconciliation an checksFocus pon weighin an dispensin operations, includin floor an bench scales, balance calibration, an environmental influences. Explain material identification, line clearance, batch reconciliation, an documentation fi ensure GMP compliance.
Scale selection an installation checksBalance calibration an verificationEnvironmental effects pon weighinMaterial ID, labelin an line clearanceBatch reconciliation an discrepancy handlinLesson 7Compression an toolin: rotary tablet press basics, turret speed, fill depth, toolin selection an punch maintenanceCover rotary tablet press construction, turret speed, fill depth, an dwell time. Explain toolin types, punch tip design, an maintenance practices fi prevent defects, reduce wear, an maintain consistent tablet quality an output.
Rotary tablet press components an functionsTurret speed, dwell time an outputDie fill depth an weight controlToolin selection an punch tip designPunch inspection, cleanin an maintenanceLesson 8Coatin equipment fundamentals: pan coatin basics vs perforated pan an rationale fi optional film coatinIntroduce coatin pans an perforated pans, atomization, an dryin zones. Explain film coatin formulation, process parameters, an when coatin is optional fi stability, taste maskin, identification, or modified release.
Conventional vs perforated coatin pansSpray guns, atomization an droplet sizeBed temperature an exhaust controlFilm coatin formulation componentsReasons fi applyin or omittin coatinLesson 9Blendin equipment: V-blender, bin blender, high-shear mixer — operatin principles an suitabilityDescribe V-blenders, bin blenders, an high-shear mixers, comparin mixin mechanisms, scale-up, an blend uniformity testin. Guide equipment selection base pon powder flow, density, an segregation risk fi robust blendin processes.
V-blender geometry an mixin patternsBin blender use in contained handlinHigh-shear mixer fi cohesive powdersBlend uniformity samplin strategiesSelectin blenders by powder propertiesLesson 10Raw material receipt, samplin an storage equipment: sacks, drums, samplin thief, controlled storage conditions, documentationAddress raw material receipt, samplin, an storage equipment, includin containers, samplin tools, an controlled environments. Cover labelin, status control, documentation, an segregation fi maintain traceability an prevent mix-ups.
Receipt checks an container inspectionSamplin plans an thief use controlsStorage conditions an monitorinLabelin, status labels an quarantineDocumentation, traceability an audits
