Lesson 1Compounding procedures for oral liquids: wetting, triturating, levigating, and homogenization techniques; equipment and in‑process controlsDis section describe stepwise compoundin of pediatric oral liquids, includin calculations, trituration, wettin, levigation, dilution, homogenization, filtration, an in-process controls to ensure uniformity, stability, an microbiological quality.
Pre-compounding checks and calculationsTrituration, wetting, and levigation stepsOrder of mixing and volume make-upHomogenization and de-aeration methodsIn-process controls and documentationLesson 2Stability, beyond‑use dating, storage, and transport for pediatric liquids; container selection and oral dosing devicesDis section detail stability factors fi pediatric liquids, includin degradation pathways, microbial risks, beyond-use datin, an how container, closure, storage, an transport conditions affect quality, safety, an dose reliability.
Degradation pathways in aqueous preparationsMicrobial growth risks and preservative needsAssigning evidence-based beyond-use datesContainer and closure selection criteriaStorage, transport, and temperature controlLesson 3Selection of dosage form: solution vs suspension vs syrup — advantages and limitationsDis section compare solutions, suspensions, an syrups fi pediatric use, outlinin advantages, limitations, an selection criteria related to API properties, dosin flexibility, stability, palatability, an risk of dosin errors.
Characteristics of oral solutionsCharacteristics of oral suspensionsCharacteristics of syrups and elixirsComparing stability and dose uniformityChoosing dosage form for specific APIsLesson 4Clinical considerations for pediatric patients: dosing by weight, formulation acceptability, and administration aidsDis section address clinical aspects of pediatric therapy wid oral liquids, includin weight-based dosin, age-appropriate volumes, formulation acceptability, administration aids, an strategies to improve adherence an minimize errors.
Weight- and BSA-based dose calculationsAge-appropriate dosing volumesAssessing taste and texture acceptabilityAdministration aids and positioningAdherence barriers and mitigationLesson 5Labeling, counseling, and safety: dosing instructions, adverse effect monitoring, measuring devices, and caregiver counselingDis section focus pon safe use of pediatric liquids through clear labellin, accurate dosin instructions, caregiver counselin, an monitorin fi adverse effects, emphasizin error prevention an correct use of measurin devices.
Essential label elements for pediatric liquidsWriting clear, error-resistant directionsSelecting and teaching dosing devicesCaregiver counseling and demonstrationMonitoring adherence and adverse effectsLesson 6Calculation workflows: converting tablet strengths to liquid concentrations and calculating beyond‑use quantities and unit dosesDis section develop calculation workflows fi extemporaneous pediatric liquids, coverin conversion of solid strengths to target concentrations, determin batch sizes, beyond-use quantities, an accurate unit-dose volumes.
Defining target concentration and volumeConverting tablets or capsules to liquidsAlligation and dilution calculationsDetermining batch size and overfillCalculating and labeling unit dosesLesson 7Excipients for oral pediatric liquids: vehicles, suspending agents, sweeteners, preservatives, buffers, and thickening agents (roles and safety limits)Dis section review excipients use in pediatric liquids, includin vehicles, sweeteners, preservatives, buffers, an thickeners, highlightin functional roles, typical concentration ranges, safety limits, an age-related restrictions.
Aqueous vehicles and cosolvent systemsSuspending and viscosity-building agentsSweeteners and flavoring for palatabilityPreservatives, buffers, and antioxidantsAge-related excipient safety concernsLesson 8Active pharmaceutical ingredient (API) properties: solubility, stability, taste masking, and pKa effects on formulationDis section examine how solubility, pKa, stability, an organoleptic profile of APIs influence pediatric liquid design, guidin selection of vehicles, pH adjustment, taste maskin strategies, an need fi suspensions or solutions.
Aqueous solubility and biopharmaceutic impactpKa, ionization, and pH adjustment strategiesChemical and physical stability in liquid mediaTaste, odor, and bitterness masking optionsChoosing solution vs suspension from API traits
