Lesson 1Pathophysiology of sepsis and septic shock: host response, organ dysfunction, and progressionExplain di host response to infection, including inflammatory an immune pathways, microcirculatory failure, an cellular dysfunction. Link dese mechanisms to organ failure, shock progression, an clinical signs nurses monitor in real time.
Host immune response to infection in sepsisEndothelial injury and capillary leakMicrocirculatory and mitochondrial dysfunctionFrom sepsis to septic shock: key transitionsOrgan dysfunction patterns and SOFA conceptsClinical correlates of underlying pathophysiologyLesson 2Fluid therapy specifics: crystalloid selection, bolus strategies, and recognition of fluid overloadCover crystalloid selection, bolus volumes, an rates in early sepsis resuscitation. Emphasize dynamic assessment of fluid responsiveness, bedside recognition of fluid overload, an nursing strategies to balance perfusion wid avoidance of harm.
Balanced versus normal saline selectionInitial bolus strategies and reassessment timingStatic and dynamic fluid responsiveness toolsClinical signs of fluid overload at the bedsideDocumentation of fluid balance and net statusCollaboration on de-resuscitation strategiesLesson 3Patient safety and sepsis-related complications: acute kidney injury, coagulopathy, and need for organ supportAddress common sepsis-related complications, including acute kidney injury, coagulopathy, respiratory failure, an need fi organ support. Emphasize early recognition, prevention strategies, an nursing care fi renal, respiratory, an hematologic support.
Recognition and staging of acute kidney injuryCoagulopathy, DIC, and bleeding riskRespiratory failure and ventilatory supportHemodynamic support beyond vasopressorsNursing care for renal replacement therapyPrevention and early detection of complicationsLesson 4Documentation and communication: recording bundle elements, escalation triggers, and handover of sepsis careDetail accurate documentation of sepsis bundles, vital trends, an interventions, along wid clear communication of escalation triggers. Emphasize structured handovers, closed-loop communication, an use of checklists to maintain continuity of care.
Recording sepsis bundle elements and timingDocumenting hemodynamics and lactate trendsEscalation triggers and rapid response criteriaStructured handover tools for sepsis patientsInterdisciplinary communication best practicesLegal and quality implications of documentationLesson 5Antimicrobial stewardship and timing: empirical therapy selection, de-escalation, and culture stewardshipFocus on timely empirical antimicrobial selection, dosing, an administration in sepsis. Review obtaining cultures, reassessing therapy wid new data, de-escalation strategies, an nursing roles in antimicrobial stewardship an monitoring toxicity.
Timing of first-dose antibiotics in sepsisEmpirical regimen selection and local antibiogramsObtaining cultures without delaying therapyDe-escalation and duration of therapyMonitoring for antimicrobial adverse effectsNursing contributions to stewardship roundsLesson 6Vasopressors and inotropes: indications, dosing targets, titration, adverse effects, and common nurse-driven protocols for norepinephrineReview norepinephrine as first-line vasopressor in septic shock, focusing on indications, starting doses, titration strategies, monitoring targets, adverse effects, an common nurse-driven protocols, including safety checks an central line considerations.
Indications for norepinephrine in septic shockStarting doses, concentration, and titration stepsMAP targets and hemodynamic monitoringRecognition and management of adverse effectsCentral line use, patency, and extravasation careNurse-driven vasopressor titration protocolsLesson 7Current international sepsis guidelines and bundles (Surviving Sepsis Campaign): 1‑hour and 3‑hour elementsSummarize current Surviving Sepsis Campaign guidelines an bundles, emphasizing 1-hour an 3-hour elements. Highlight time-sensitive nursing actions, local protocol adaptation, an audit-feedback processes to improve adherence an patient outcomes.
Core principles of Surviving Sepsis CampaignOne-hour bundle elements and nurse actionsThree-hour bundle elements and sequencingIntegrating bundles into unit workflowsMeasuring compliance and feedback loopsAdapting guidelines to local resourcesLesson 8Hemodynamic goals in sepsis: MAP targets, lactate-guided resuscitation, and fluid responsiveness assessmentDefine hemodynamic goals in sepsis, including MAP targets, lactate clearance, an markers of perfusion. Review bedside assessment of fluid responsiveness an integration of dynamic indices, ultrasound, an clinical judgment in resuscitation decisions.
MAP targets and individualized blood pressure goalsLactate trends and perfusion-guided resuscitationCapillary refill and peripheral perfusion markersDynamic indices for fluid responsivenessRole of bedside ultrasound in volume assessmentBalancing fluids, vasopressors, and inotropesLesson 9Monitoring response to sepsis treatment: serial lactates, urine output, end-organ perfusion markers, and bedside clinical toolsDescribe how to monitor response to sepsis treatment using serial lactates, urine output, mental status, an other end-organ markers. Cover bedside tools, frequency of reassessment, an documentation to guide ongoing resuscitation an de-escalation.
Serial lactate measurement and interpretationUrine output targets and renal perfusionNeurologic status and delirium screeningSkin, temperature, and perfusion assessmentFrequency and structure of reassessment roundsTrend-based documentation and care adjustmentsLesson 10Infection source control: principles, timelines, and nursing coordination for procedures and diagnosticsOutline principles of infection source control, including timing, coordination of imaging an procedures, an communication wid di multidisciplinary team. Highlight nursing roles in preparation, transport, consent support, an postprocedure monitoring.
Identifying likely infection sources earlyTiming and urgency of source control actionsCoordinating imaging and bedside proceduresPreprocedure preparation and safety checksPostprocedure monitoring and complication signsNursing role in multidisciplinary planning
