Lesson 1Active dosing plan: selecting an effective yet tolerable percentage range and rationaleDis section teach how fi set active levels weh effective yet tolerable. Yu wi interpret literature, in vivo data, an regulatory limits, define starting ranges, an plan stepwise optimization while managin cumulative exposure inna routines.
Reading literature and supplier dataMinimum effective vs plateau dosesSafety margins and irritation thresholdsLayering with other products in a routinePilot batches and consumer feedback loopsLesson 2Solvents and co-solvents selection: water, glycols, propanediol, oils — impact on solubility and stabilityDis section focus pon choosin solvents an co-solvents such as water, glycols, propanediol, an oils. Yu wi see how polarity, volatility, an miscibility affect solubility, stability, skin feel, an delivery a hydrophilic an lipophilic actives.
Water quality and microbiological controlUsing glycols to improve solubilityPropanediol as humectant co-solventOil phase choice for lipophilic activesSolvent impact on stability and feelLesson 3Emollients and skin-feel modifiers: lightweight esters, caprylic/capric triglycerides, squalane — balancing aesthetics and skin toleranceDis section examine emollients an skin-feel modifiers, includin esters, caprylic/capric triglycerides, an squalane. Yu wi learn fi tune spreadability, richness, an afterfeel while supportin barrier function an active tolerability.
Lightweight esters for fast absorptionCaprylic/capric triglycerides as base emollientSqualane for barrier support and slipSilicone vs non-silicone feel strategiesComedogenicity and skin type matchingLesson 4Antioxidants and stabilizers to protect actives: vitamin E (tocopherol), ferulic acid, chelators (EDTA), and rationaleDis section cover antioxidants an stabilizers weh protect sensitive actives from oxidation an degradation. Yu wi study vitamin E, ferulic acid, chelators like EDTA, an how fi design synergistic systems matched to formula type an packaging.
Oxidation pathways in cosmetic formulasVitamin E (tocopherol) in oil phasesFerulic acid to support vitamin C systemsChelators such as EDTA and alternativesPackaging and oxygen exposure controlLesson 5Humectants and moisturizers: role of glycerin, propanediol, sodium hyaluronate, butylene glycol and selection guidanceDis section explore humectants an moisturizers such as glycerin, propanediol, sodium hyaluronate, an butylene glycol. Yu wi learn how fi combine dem fi balance hydration, tackiness, penetration, an compatibility wid actives.
Glycerin levels and tack controlPropanediol as mild humectant solventSodium hyaluronate grades and weightsButylene glycol for slip and solvencyHumectant blends for different climatesLesson 6Designing the serum type: water-based serum, emulsion serum, anhydrous serum — selection matrix based on chosen activeDis section guide selection a serum type base pon active profile. Yu wi compare water-based, emulsion, an anhydrous serums, usin a decision matrix weh weigh solubility, stability, sensory goals, packaging, an consumer expectations.
Water-based serums for hydrophilic activesEmulsion serums for mixed solubility needsAnhydrous serums for unstable activesDecision matrix by active and skin typePackaging choices for each serum typeLesson 7Thickeners and texture agents: carbomers, xanthan gum, polyacrylate rheology modifiers and considerations for clarity vs opacityDis section detail how thickeners an rheology modifiers shape texture, spreadability, an suspension. Yu wi compare carbomers, xanthan gum, an polyacrylates, an learn how fi tune clarity, opacity, an sensory feel fi different product formats.
Carbomer types and neutralization needsXanthan gum for natural, elastic texturesPolyacrylate rheology modifiers in gelsBalancing clarity, opacity, and viscosityPreventing syneresis and phase separationLesson 8pH adjusters and buffers: selection and how to control formula pH to protect actives and skin compatibilityDis section explain how fi select pH adjusters an buffers fi protect actives an skin. Yu wi learn fi choose acids, bases, an buffer pairs, measure an fine-tune pH, an prevent drift over shelf life an durin consumer use.
Target pH ranges for key activesCommon acids and bases for adjustmentBuffer systems and ionic strengthpH drift causes and preventionpH measurement and calibration basicsLesson 9Preservative systems and strategies for low-irritancy formulas: preservative selection, boosting with chelators, and preservative compatibilityDis section explain preservative system design fi low-irritancy formulas. Yu wi compare common preservatives, boosting wid chelators an humectants, an evaluate compatibility wid pH, surfactants, an natural claims while meetin safety standards.
Regulatory limits and global preservative listsOrganic acids and pH-dependent systemsPreservative boosting with chelatorsSynergy with humectants and glycolsChallenge testing and risk assessmentLesson 10Penetration enhancers and delivery systems: role of solvents, short-chain alcohols, propylene glycol, esters, and encapsulation approaches (liposomes, solid lipid nanoparticles)Dis section explain how penetration enhancers an delivery systems work, coverin common solvents, short-chain alcohols, glycols, esters, an modern encapsulation systems fi improve active solubility, stability, an skin targeting while limitin irritation.
Role of solvent polarity in skin permeationShort-chain alcohols: efficacy vs irritationUse of glycols and propylene glycolEster-based penetration enhancersLiposomes and solid lipid nanoparticles
