Lesson 1Compounding procedures for oral liquids: wetting, triturating, levigating, and homogenization techniques; equipment and in‑process controlsThis part describes step-by-step making of paediatric oral liquids, including calculations, grinding, wetting, levigating, diluting, mixing well, filtering, and checks during process to ensure evenness, stability, and no germs.
Pre-compounding checks and calculationsTrituration, wetting, and levigation stepsOrder of mixing and volume make-upHomogenization and de-aeration methodsIn-process controls and documentationLesson 2Stability, beyond‑use dating, storage, and transport for pediatric liquids; container selection and oral dosing devicesThis part details what affects stability of paediatric liquids, like breakdown paths, germ risks, use-by dates, and how containers, lids, storage, and moving them keep quality, safety, and right doses.
Degradation pathways in aqueous preparationsMicrobial growth risks and preservative needsAssigning evidence-based beyond-use datesContainer and closure selection criteriaStorage, transport, and temperature controlLesson 3Selection of dosage form: solution vs suspension vs syrup — advantages and limitationsThis part compares solutions, suspensions, and syrups for kids, listing good points, limits, and choices based on drug properties, dosing ease, stability, taste, and risks of wrong doses.
Characteristics of oral solutionsCharacteristics of oral suspensionsCharacteristics of syrups and elixirsComparing stability and dose uniformityChoosing dosage form for specific APIsLesson 4Clinical considerations for pediatric patients: dosing by weight, formulation acceptability, and administration aidsThis part covers patient care for kids using oral liquids, like weight-based doses, right volumes for age, if they like the taste, tools for giving medicine, and ways to help them take it properly.
Weight- and BSA-based dose calculationsAge-appropriate dosing volumesAssessing taste and texture acceptabilityAdministration aids and positioningAdherence barriers and mitigationLesson 5Labeling, counseling, and safety: dosing instructions, adverse effect monitoring, measuring devices, and caregiver counselingThis part stresses safe use of paediatric liquids with clear labels, right dose instructions, advice for caregivers, watching for side effects, and using correct measuring tools to avoid mistakes.
Essential label elements for pediatric liquidsWriting clear, error-resistant directionsSelecting and teaching dosing devicesCaregiver counseling and demonstrationMonitoring adherence and adverse effectsLesson 6Calculation workflows: converting tablet strengths to liquid concentrations and calculating beyond‑use quantities and unit dosesThis part builds calculation steps for paediatric liquids from scratch, changing tablet strengths to liquid levels, figuring batch sizes, use-by amounts, and exact single doses.
Defining target concentration and volumeConverting tablets or capsules to liquidsAlligation and dilution calculationsDetermining batch size and overfillCalculating and labeling unit dosesLesson 7Excipients for oral pediatric liquids: vehicles, suspending agents, sweeteners, preservatives, buffers, and thickening agents (roles and safety limits)This part reviews helpers in paediatric liquids like carriers, suspenders, sweeteners, preservatives, buffers, thickeners, their jobs, usual amounts, safety limits, and rules by age.
Aqueous vehicles and cosolvent systemsSuspending and viscosity-building agentsSweeteners and flavoring for palatabilityPreservatives, buffers, and antioxidantsAge-related excipient safety concernsLesson 8Active pharmaceutical ingredient (API) properties: solubility, stability, taste masking, and pKa effects on formulationThis part looks at how drug dissolving, pKa, stability, and taste affect paediatric liquid making, helping choose carriers, pH changes, hide bad taste, and if suspension or solution is best.
Aqueous solubility and biopharmaceutic impactpKa, ionization, and pH adjustment strategiesChemical and physical stability in liquid mediaTaste, odor, and bitterness masking optionsChoosing solution vs suspension from API traits
