Lesson 1Pressing Tablets: How the Tablet Press Works, Tools, Feed System, Weight Checks, and Main ProblemsThis lesson covers parts of the tablet press, how to set it up, and running it. It explains caring for tools, controlling weight and hardness, and usual issues like capping, splitting, and sticking, with ways to fix them simply.
Types of presses, main parts, and safety guardsChoosing, checking, and cleaning toolsDesign of feed frame and powder flow problemsControlling weight, hardness, and thicknessCapping, splitting, sticking, and pickingLesson 2Ways to Granulate: Wet Granulation Steps, Machine Use, and Key SettingsThis lesson details steps in wet granulation, choosing binders, and types of machines. It covers important settings, scaling up, and cleaning, stressing checks to ensure good granules for flow and pressing later.
Preparing binder solution and checksSetting up and running high-shear granulatorFinding end-point and using PAT toolsTransferring granules and wet screeningScaling up and cleaning requirementsLesson 3Handling Materials: Active Ingredients, Additives, Sampling, Holding Back, and Release RulesThis lesson reviews handling active ingredients and additives from arrival to release. It includes sampling, holding back, storage, and environment controls, focusing on stopping cross-contamination and releasing based on specs.
Receiving and labeling active ingredients and additivesSampling plans, tools, and contamination risksHolding back, approved, and rejected statusStorage conditions and separation rulesReviewing COA, testing, and release rulesLesson 4Packing: Blister Line Work, Checks for Strength, Labeling, and Tracking NumbersThis lesson describes main and outer packing for solid orals, focusing on blister lines. It covers forming, feeding, sealing, coding, checking, labeling, and tracking, with controls to keep identity and product strength safe.
Steps in blister forming, feeding, and sealingCartoning, inserting leaflets, and bundlingOnline vision systems and seal strengthCoding, tracking, and groupingPacking line records and yieldsLesson 5Direct Pressing: Suitability of Formula, Choosing Additives, and Process ChecksThis lesson focuses on if direct pressing works, including active ingredient traits, choosing additives, and flow. It explains lubrication, separation risks, and checks needed for strong tablets without granulating first.
Active ingredient traits key for direct pressingChoosing fillers, binders, and break-apart agentsUsing pre-granulated and co-processed additivesLubricant amount, mixing order, and effectsProcess checks and usual failure modesLesson 6Coating and Extra Steps (Short): When to Use and Basic Process PointsThis lesson introduces film coating and other extra steps like printing and capsule marking. It outlines when coating is needed, key process changes, machine basics, and common faults with fixing steps.
Purposes of functional and non-functional coatingBasics of coating pan and spray systemControl of inlet air, exhaust, and spray rateCommon coating faults and causesPrinting, pressing marks, and capsule bandingLesson 7Drying and Grinding: Moisture Control, Drying Checks, Particle Size Reduction and EffectsThis lesson explains drying basics, moisture limits, and dryer types. It covers load setup, end-point finding, and checks, then connects grinding, particle size spread, and heat to mix evenness and pressing.
Moisture goals and loss on drying testsBasics of fluid bed and tray dryer operationDrying end-point, sampling, and checksTypes of grinding machines and key settingsPSD effects on flow, pressing, and faultsLesson 8Handover Between Steps: Line Clearing, Material Moving, and Sampling Points During ProcessThis lesson explains controlled handover between steps, including line clearing, status labeling, and material moving. It details sampling points in process, duties, and records to avoid mix-ups and missing data.
Scope and records of line clearingLabels for material status and moving rulesDefined roles and duties in handoverPlans and places for in-process samplingHandling samples, storage, and chain of custodyLesson 9Mixing and Blending Basics: Even Blend, Separation Risks, Mixing ChecksThis lesson explains mixing ways, blender types, and testing for even blend. It covers separation risks, addition order, scaling up, and check methods to show reliable, repeatable mixing.
Types of blenders and loading waysMixing ways and time findingSampling plans for blend evenness testsCauses of separation and fixing methodsMixing checks and ongoing proofLesson 10Weighing and Dispensing: Steps, Accuracy, Tare, and TrackingThis lesson covers weighing room setup, balance checks, and right tare use. It explains sampling, ID, matching, labeling, and tracking controls for accurate dispensing and full material history.
Zoning and environment controls in weighing roomBalance calibration, proof, and upkeepTare steps and reducing handling mistakesMaterial ID, labels, and status controlWeighing records, matching, and historyLesson 11Overview of Making Tablets and Capsules from Raw Materials to Final PackingThis lesson maps the full making flow from raw material arrival to finished packs. It highlights records, sampling, in-process checks, and decision points, connecting each stage to GMP, data truth, and batch release needs.
Raw material arrival, sampling, and testingIssuing batch records and line prepCore processing through pressing or fillingCoating, printing, and visual checksFinal packing, QA review, and release
