Lesson 1Immediate pharmacologic measures for suspected MI: aspirin dosing, P2Y12 inhibitors selection and timing (clopidogrel, prasugrel, ticagrelor)Outlines right-away drug steps for suspected MI, stressing fast aspirin, picking/timing P2Y12 inhibitors, loading doses, linking with blood thinners and reperfusion, and noting allergies or past treatment.
Aspirin loading dose and formulationsChoosing initial P2Y12 inhibitor in EDTiming of loading relative to PCI or lysisManaging prior DAPT or recent anticoagulantsDocumenting allergies and prior stent historyLesson 2Oxygen therapy and adjunctive measures: indications for supplemental oxygen and non-invasive ventilationReviews when to use extra oxygen and non-invasive breathing help in ACS, stressing not routine oxygen in normal oxygen levels, start points, device picks, and linking with blood flow and pain control.
Evidence against routine oxygen in normoxiaSpO2 thresholds to start supplemental oxygenChoosing nasal cannula vs mask vs HFNCIndications for CPAP or BiPAP in ACSMonitoring respiratory status and escalationLesson 3Reperfusion decision-making: criteria for primary PCI vs fibrinolysis vs conservative managementGuides reperfusion choices in STEMI and some NSTEMI, outlining primary PCI criteria, when fibrinolysis fits, time limits, no-gos, and when watchful waiting suits based on lack of blood and bleed risks.
STEMI criteria and symptom onset timingDoor-to-balloon and door-to-needle goalsAbsolute and relative lysis contraindicationsWhen to choose primary PCI over lysisConservative strategy in high-risk NSTEMILesson 4Fibrinolytic agents: indications, dosing (tenecteplase, alteplase), contraindications, and management of bleeding complicationsCovers clot-busters for STEMI when PCI delays, weight doses for tenecteplase/alteplase, extra blood thinners, no-gos, and spotting/handling bleeding.
STEMI patients eligible for fibrinolysisTenecteplase dosing by weight and ageAlteplase STEMI dosing protocolsAdjunct aspirin and anticoagulation useManaging intracranial and systemic bleedingLesson 5Special scenarios: cardiogenic shock, cardiac arrest with STEMI, right ventricular infarction — tailored reperfusion and pharmacologic adjustmentsHandles tricky ACS cases like heart shock, arrest with STEMI, right heart infarct, focusing custom reperfusion, blood flow support, careful tweaks to pressors and vasoactives.
Identifying and grading cardiogenic shockMechanical support options in shockPost–cardiac arrest STEMI pathwaysRight ventricular infarction recognitionAdjusting preload, afterload, and inotropesLesson 6Nitrates, morphine, and hemodynamic considerations: indications, contraindications, and administration routesLooks at nitrates and morphine in ACS, when for symptom ease, no-gos like low pressure or right infarct, ways to give, doses, effects on preload, afterload, heart blood flow.
Contraindications to nitrate therapySublingual vs IV nitrate administrationMorphine dosing and monitoringImpact on preload and afterloadInteractions with phosphodiesterase-5 inhibitorsLesson 7Renal dysfunction and drug selection: dose adjustments, contrast nephropathy prevention, and anticoagulation changes in CKDFocuses on ACS with kidney issues, dose tweaks for blood thinners/contrast, plans to stop contrast kidney harm, fluids, balancing lack of blood and bleed risks in bad kidneys.
Estimating kidney function in the EDAdjusting anticoagulants in CKD and ESRDP2Y12 and statin choices in renal diseaseHydration and contrast minimization tacticsPost-contrast monitoring and nephrology consultsLesson 8Anticoagulation choices in ACS: UFH, bivalirudin, enoxaparin — dosing, monitoring, renal adjustments, and periprocedural considerationsCompares blood thinners in ACS like UFH, enoxaparin, bivalirudin, stressing doses in STEMI/NSTEMI, watch plans, kidney tweaks, handling around PCI/CABG.
UFH bolus and infusion dosing in ACSEnoxaparin dosing and timing with PCIBivalirudin indications and dosingMonitoring ACT, aPTT, and anti-Xa levelsBridging and holding anticoagulants for CABGLesson 9Antiplatelet management in NSTEMI: timing of loading doses before coronary angiography and scenarios favoring conservative vs early invasive approachHandles antiplatelet in NSTEMI, timing aspirin/P2Y12 loads before angio, agent choice, how lack of blood/bleed risk, other ills, planned work sway watchful vs early invasive.
Risk scores guiding invasive strategyTiming of P2Y12 loading before cathChoosing clopidogrel vs ticagrelor vs prasugrelManaging patients likely to need CABGDe-escalation and duration of DAPT in NSTEMILesson 10Primary PCI pathways: door-to-balloon targets, transfer protocols, pre-PCI medications, and antithrombotic strategyDetails main PCI flows, door-to-balloon goals, start/transfer plans, pre-PCI antiplatelet/anticoag, tailoring blood thinner plans to bleed risk/lesion toughness.
ED triage and cath lab activation stepsInterfacility transfer and transport timingPre-PCI aspirin and P2Y12 loadingChoice of UFH, bivalirudin, or enoxaparinPost-PCI antithrombotic continuation plansLesson 11Beta-blockers and ACE inhibitors/ARBs in acute setting: when to give, contraindications, initial dosing and monitoringReviews early beta-blockers/ACEi/ARBs in ACS, timing post-stable, no-gos like shock/brady, start doses, ramp up, watch for low pressure, kidney harm, high potassium.
Hemodynamic criteria before beta-blockersOral vs IV beta-blocker selectionStarting and titrating ACEI or ARBContraindications and caution flagsMonitoring blood pressure, creatinine, potassiumLesson 12High-intensity statin initiation in ED: rationale, dosing, and hepatic safety checksExplains starting strong statins in ED for ACS, evidence for early go, right agents/doses, liver baseline, enzyme watch, handling statin issues.
Evidence for early statin in ACS outcomesChoosing atorvastatin vs rosuvastatinInitial high-intensity dosing regimensBaseline liver tests and contraindicationsMonitoring and managing hepatic adverse events
